Nytol Tablets One-A-Night 50mg Pack of 20


  • Clinically Proven Sleep Aid
  • One pack provides a 20 day supply
  • Short Term Use Only
  • Contains Diphenhydramine


Nytol Tablets One-A-Night are an antihistamine used to help you relax and fall asleep, it reduces alertness and promotes that first drowsy stage of sleep, helping you to then drift off into a restful, deeper sleep.

They work by blocking the normal actions of histamine, which is the chemical that stimulates arousal-promoting areas of the brain in order to reduce alertness and promote that first stage of drowsiness. Once in that first stage of sleep, you’ll find it much easier to naturally drift off into a deep and restful sleep so that you can feel fully refreshed in the morning.


What is Nytol One a Night?

Nytol One a Night is an antihistamine medicine which helps the patient relax and to fall asleep, it is
shown to increase early drowsiness helping to ease the patient into a restful and deeper sleep.

Is Nytol right for me?

Nytol One a Night is suitable for those who suffer from short term insomnia. You should not take
this medication if any of the warnings in the information leaflet apply to you.

How does Nytol work?

Nytol One-A-night tablets is an antihistamine medicine, this means when a tablet is taken it blocks
the normal actions of histamine which stop making the brain aroused. Each tablet contains 50mg of
diphenhydramine hydrochloride, this helps to reduce alertness and helping you to fall into the first
drowsy stage of sleep allowing the patient to have restful and deeper sleep.

Can I drink alcohol if I take Nytol?

No. If you take Nytol you cannot drink alcohol whilst taking this medication.

Can I drive/operate machinery if I have taken Nytol?

No. You cannot drive or operate machinery if you have taken Nytol as the purpose of the medication
is to cause drowsiness in order to aid sleep.

Can I take Nytol One a Night if I am pregnant or breastfeeding?

No. If you are pregnant or breastfeeding it is advised that you speak to your own GP.


Take 1 tablet 20 minutes before bed. 


– The active substance: Each tablet contains Diphenhydramine Hydrochloride 50 mg.

– The other ingredients are: Anhydrous lactose, microcrystalline cellulose, maize starch, stearic acid and silicon dioxide.


Do not take Nytol One-A-Night:

  • if you have ever had an allergic reaction to diphenhydramine hydrochloride or any of the other
  • if you have an obstruction in your stomach or gut (for example, because of an ulcer).

Warnings and precautions
Talk to your doctor or pharmacist before taking Nytol One-A-Night:

  • if you have asthma, bronchitis or Chronic Obstructive Pulmonary Disease (COPD)
  • if you have narrow-angle glaucoma (a form of raised pressure in the eye)
  • if you have an enlarged prostate or urinary retention
  • if you have moderate to severe liver or kidney disease
  • if you have myasthenia gravis, epilepsy or seizure disorders.
  • If your sleeping difficulties persist, talk to your doctor or pharmacist.
  • Nytol One-A-Night may get less effective if you use it continuously.

Other medicines and Nytol One-A-Night
Talk to your doctor or pharmacist before taking these tablets if you are taking any prescribed medicines; particularly tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs prescribed for depression) within the last two weeks, medicine used to dilate pupils of the eyes or medicines which make you drowsy. Avoid the use of other antihistamines including those used on your skin and in cold and cough medicines, while taking this medicine. Do not drink alcohol while using Nytol One-A-Night.

Do not drive or operate machinery. Nytol One-A-Night is intended to produce sleepiness or drowsiness soon after the dose is taken.